Dipanjan Pan

Professor

Contact Information

University of Maryland, School of Medicine

Pan Lab website

Education

Postdoc. Chemistry/Polymer/Nanotechnology– Washington University in St Louis, 2005

Ph.D. Chemistry – Indian Institute of Technology, Kharagpur, 2002
M.S. Chemistry – Vidyasagar University, 1997

Research Interests

Dipanjan Pan is leading the Laboratory for Materials in Medicine (MatMed) at UMB and UMBC. MatMed’s mission is to develop next generation translatable technologies to improve human health by uniquely merging ‘molecule making’ and ‘device making’, and through innovations in nanomedicine tools and point-of-care diagnostic systems. Active research themes include:

• Fundamentals: nanoparticle synthesis, drug discovery and controlled delivery, molecular imaging, biosensing
• Applications: cancer stem cell, immune-therapeutics, drug-free antimicrobial, disease diagnosis/monitoring, image-guided prototyping

Select Publications – PubMed

• Dahal D, Ray P, Pan D. Unlocking the power of optical imaging in the second biological window: Structuring near-infrared II materials from organic molecules to nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Nov;13(6):e1734.
• Moitra P, Alafeef M, Dighe K, Ray P, Chang J, Thole A, Punshon-Smith B, Tolosa M, Ramamurthy SS, Ge X, Frey DD, Pan D, Rao G. Rapid and low-cost sampling for detection of airborne SARS-CoV-2 in dehumidifier condensate. Biotechnol Bioeng. 2021 Aug;118(8):3029-3036.
• Alafeef M, Moitra P, Dighe K, Pan D. Hyperspectral Mapping for the Detection of SARS-CoV-2 Using Nanomolecular Probes with Yoctomole Sensitivity. ACS Nano. 2021 Jul 19;.
• Ostadhossein F, Moitra P, Altun E, Dutta D, Sar D, Tripathi I, Hsiao SH, Kravchuk V, Nie S, Pan D. Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance. Commun Biol. 2021 Jul 15;4(1):846.
• Moitra P, Alafeef M, Dighe K, Sheffield Z, Dahal D, Pan D. Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2. Chem Commun (Camb). 2021 Jun 24;57(51):6229-6232.
• Alafeef M, Moitra P, Dighe K, Pan D. RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19. Nat Protoc. 2021 Jun;16(6):3141-3162.
• Fontana F, Scott MJ, Allen JS, Yang X, Cui G, Pan D, Yanaba N, Fiala MA, O’Neal J, Schmieder-Atteberry AH, Ritchey J, Rettig M, Simons K, Fletcher S, Vij R, DiPersio JF, Lanza GM. VLA4-Targeted Nanoparticles Hijack Cell Adhesion-Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival. Clin Cancer Res. 2021 Apr 1;27(7):1974-1986.
• Nguyen HA, Srivastava I, Pan D, Gruebele M. Ultrafast nanometric imaging of energy flow within and between single carbon dots. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11).
• Fathi P, Roslend A, Mehta K, Moitra P, Zhang K, Pan D. UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles. Nanoscale. 2021 Mar 12;13(9):4785-4798.
• Alafeef M, Dighe K, Moitra P, Pan D. Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip. ACS Nano. 2020 Oct 20;.
• Fathi P, Pan D. Current trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications. Nanomedicine (Lond). 2020 Oct;15(25):2493-2515.
• Alafeef M, Moitra P, Pan D. Nano-enabled sensing approaches for pathogenic bacterial detection. Biosens Bioelectron. 2020 Oct 1;165:112276.
• Schwartz-Duval AS, Konopka CJ, Moitra P, Daza EA, Srivastava I, Johnson EV, Kampert TL, Fayn S, Haran A, Dobrucki LW, Pan D. Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold. Nat Commun. 2020 Sep 10;11(1):4530.
• Huang Z, Wang D, Ayele BA, Zhou J, Srivastava I, Pan D, Wang Z, Chen Q. Enhancement of auxiliary agent for washing efficiency of diesel contaminated soil with surfactants. Chemosphere. 2020 Aug;252:126494.
• Patel PR, Senyuk V, Sweiss K, Calip GS, Pan D, Rodriguez N, Oh A, Mahmud N, Rondelli D. PARP Inhibition Synergizes with Melphalan but Does not Reverse Resistance Completely. Biol Blood Marrow Transplant. 2020 Jul;26(7):1273-1279.
• Hamideh RA, Akbari B, Fathi P, Misra SK, Sutrisno A, Lam F, Pan D. Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks. Adv Healthc Mater. 2020 Jul;9(14):e2000136.
• Alafeef M, Srivastava I, Pan D. Machine Learning for Precision Breast Cancer Diagnosis and Prediction of the Nanoparticle Cellular Internalization. ACS Sens. 2020 Jun 26;5(6):1689-1698.
• Moitra P, Alafeef M, Dighe K, Frieman MB, Pan D. Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles. ACS Nano. 2020 Jun 23;14(6):7617-7627.
• Nguyen HA, Srivastava I, Pan D, Gruebele M. Unraveling the Fluorescence Mechanism of Carbon Dots with Sub-Single-Particle Resolution. ACS Nano. 2020 May 26;14(5):6127-6137.
• Srivastava I, Misra SK, Bangru S, Boateng KA, Soares JANT, Schwartz-Duval AS, Kalsotra A, Pan D. Complementary Oligonucleotide Conjugated Multicolor Carbon Dots for Intracellular Recognition of Biological Events. ACS Appl Mater Interfaces. 2020 Apr 8;12(14):16137-16149.
• Ostadhossein F, Sar D, Tripathi I, Soares J, Remsen EE, Pan D. Oligodots: Structurally Defined Fluorescent Nanoprobes for Multiscale Dual-Color Imaging in Vitro and in Vivo. ACS Appl Mater Interfaces. 2020 Mar 4;12(9):10183-10192.
• Fathi P, Capron G, Tripathi I, Misra S, Ostadhossein F, Selmic L, Rowitz B, Pan D. Computed tomography-guided additive manufacturing of Personalized Absorbable Gastrointestinal Stents for intestinal fistulae and perforations. Biomaterials. 2020 Jan;228:119542.
• Alafeef M, Dighe K, Pan D. Label-Free Pathogen Detection Based on Yttrium-Doped Carbon Nanoparticles up to Single-Cell Resolution. ACS Appl Mater Interfaces. 2019 Nov 20;11(46):42943-42955.
• Ostadhossein F, Tripathi I, Benig L, Lobato D, Moghiseh M, Lowe C, Raja A, Butler A, Panta R, Anjomrouz M, Chernoglazov A, Pan D. Multi‐“Color” Delineation of Bone Microdamages Using Ligand‐Directed Sub‐5 nm Hafnia Nanodots and Photon Counting CT Imaging. Advanced Functional Materials. 2019 November.
• Pandit S, Banerjee T, Srivastava I, Nie S, Pan D. Machine Learning Assisted Array-based Biomolecular Sensing Using Surface Functionalized Carbon Dots. ACS Sens. 2019 (ASAP)
• Srivastava I, Khamo JS, Subhendu P, Fathi P, Huang X, Cao A, Haasch RT, Nie S, Zhang K, Pan D. Influence of Electron Acceptor and Electron Donor on the Photophysical Properties of Carbon Dots. A Comparative Investigation at the Bulk-State and Single-Particle Level. Adv. Funct. Mater. 2019, 1902466.
• Fathi P, Knox HJ, Sar D, Tripathi I, Ostadhossein F, Misra SK, Esch MB, Chan J, Pan D. Biodegradable Biliverdin Nanoparticles for Efficient Photoacoustic Imaging. ACS Nano. 2019 Jul 23;13(7):7690-7704.
• Datta S, Misra SK, Saha ML, Lahiri N, Louie J, Pan D, Stang PJ. Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8087-8092.
• Ye M, Misra SK, De AK, Ostadhossein F, Singh K, Rund L, Schook L, Pan D. Design, Synthesis, and Characterization of Globular Orphan Nuclear Receptor Regulator with Biological Activity in Soft Tissue Sarcoma. J Med Chem. 2018 Dec 13;61(23):10739-10752.
• Ostadhossein F, Misra SK, Tripathi I, Kravchuk V, Vulugundam G, LoBato D, Selmic LE, Pan D. Dual purpose hafnium oxide nanoparticles offer imaging Streptococcus mutans dental biofilm and fight it In vivo via a drug free approach. Biomaterials. 2018 Oct;181:252-267.
• Misra SK, De A, Pan D. Targeted Delivery of STAT-3 Modulator to Breast Cancer Stem-Like Cells Downregulates a Series of Stemness Genes. Mol Cancer Ther. 2018 Jan;17(1):119-129.
• Misra SK, Dighe K, Schwartz-Duval AS, Shang Z, Labriola LT, Pan D. In situ plasmonic generation in functional ionic-gold-nanogel scaffold for rapid quantitative bio-sensing. Biosens Bioelectron. 2018 Nov 30;120:77-84.
• Khan MS, Misra SK, Dighe K, Wang Z, Schwartz-Duval AS, Sar D, Pan D. Electrically-receptive and thermally-responsive paper-based sensor chip for rapid detection of bacterial cells. Biosens Bioelectron. 2018 Jul 1;110:132-140.