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Mark R. Marten


Professor & Department Chair

Contact Information

Engineering, Room 314

Marten Lab Website

Ph.D. Chemical Engineering – Purdue University, 1991
M.S. Chemical Engineering – Purdue University, 1988
B.S. Chemical Engineering – State University of New York at Buffalo, 1986

Research Interests

The broad goal in my laboratory is to better understand, and then beneficially manipulate, microbial expression systems. While we have carried out some projects involving bacteria, our primary focus is on filamentous fungi. We use a sophisticated set of analytical tools (electron microscopy, digital image analysis, atomic force microscopy) to asses fungal morphology and the physical properties of fungal cell walls. As an important tool in our molecular studies, we use a functional-genomic technique called proteomic analysis. This process involves the identification and quantification of individual proteins from various cellular fractions (e.g., cytoplasm, vacuoles, cell wall). These data are used for differential comparison allowing us to make deductions about cellular mechanisms. We are also developing new ways to use proteomic analysis to study cellular signaling pathways (phospho-proteomics).  Recently, we have used all of these tools to better understand a fundamental cellular recycling-pathway called autophagy. And currently, we are studying the relationship between fungal morphology and protein secretion.

Selected Publications – Google Scholar – Pubmed


Liliane F. C. Ribeiro, Cynthia Chelius, Karthik R. Boppidi, Nisha S. Naik*, Simin Hossain, Jessica J.J.L.A. Ramsey*, Jyothi Kumar, Lucas F. Ribeiro, Marc Ostermeier, Bao Tran, Young Ah Goo, Leandro J. de Assis, Gustavo H. Goldman, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Marten, “Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation,” mBio, 10(2):e02825-18, 2019.

Cynthia L. Chelius, Liliane Ribiero, Jyothi Kumar, Stephen Lincoln, Bao Tran, Young Ah Goo, Ranjan Srivastava, Steven D. Harris, Mark R. Marten, “Phosphoproteomic and transcriptomic analyses reveal multiple functions for Aspergillus nidulans MpkA independent of cell wall stress.” Fungal Genetics and Biology, 125:1–12, 2019.

Karthik R. Boppidi, Liliane FC Ribeiro, Sirasa Iambamrung*, Sidney M. Nelson*, Yan Wang, Michelle Momany, Elizabeth A. Richardson, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Marten, “Altered secretion patterns and cell wall organization caused by loss of PodB function in the filamentous fungus Aspergillus nidulans.” Scientific Reports, 8(1), 11433, 2018.

Daniela Quintanilla, Cynthia Chelius, Sirasa Iambamrung*, Sidney Nelson*, Donnel Thomas*, Krist V. Gernaey, Mark R. Marten, “A fast and simple method to estimate relative, hyphal tensile-strength of filamentous fungi used to assess the effect of autophagy.” Biotechnology & Bioengineering, 115(3): 597-605, 2018.

Liliane FC Ribeiro, Cynthia L Chelius, Steven D Harris and Mark R. Marten, “Insights Regarding Fungal Phosphoproteomic Analysis.” Fungal Genetics and Biology, 104:38-44, 2017.