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Gregory L. Szeto

IMME logoTitle

Assistant Professor

Contact Information

ILSB 415

Szeto Lab Website (Immune Mechanism and Modulation Engineering; IMME)

NIH NCI F32 Postdoctoral Fellow – Massachusetts Institute of Technology; Ragon Institute of MGH, MIT and Harvard, 2015
Ph.D. Cellular & Molecular Medicine – Johns Hopkins University School of Medicine, 2010
B.S. Chemical Engineering – Carnegie Mellon University, 2004
B.S. Biomedical & Health Engineering – Carnegie Mellon University, 2004

Research Interests

Our highly interdisciplinary research focuses on utilizing engineering approaches (drug delivery, biomaterials, systems biology) to 1) identify and compensate for deficient immune signal processing in tumor-suppressed cell networks, 2) create novel, integrative immuno-diagnostic and -prognostic platforms (in silicoin vitro) to optimize patient interventions via rational design of immune modulation, and 3) develop new classes of local, metabolism-focused immunotherapies. A unique combination of strengths fuels our work including basic and clinical immunology, systems biology, biomaterials, and novel platforms and devices. These skills will be used to provide solutions for urgent needs in cancer and vaccine development as well as clinical immunomonitoring. We work closely with the University of Maryland Medical School, notably the Tumor Immunology & Immunotherapy Program in the Marlene and Stewart Greenebaum Cancer Center.

Publications (* denotes equal authorship) – Google Scholar – Pubmed
  1. Moynihan KD*, Opel CF*, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kwan BH, Abraham W, Hu K, Kauke MJ, Suh H, Lauffenburger DA, Wittrup KD, Irvine DJ. “Eradication of large established tumors by combination immunotherapy engaging innate and adaptive immunity.” Submitted, 2016.
  2. Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard A, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark N, Jones M, Kou Y, Jenkins SL, Woodland H, Amaral F, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bengoetxea X, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dischuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Devlin TD, Pérez-García V, Ma’ayan A. “Extraction and Analysis of Mammalian Gene Expression Signatures from GEO by the Crowd.” Submitted, 2015.
  3. Kimmerling R, Szeto GL, Li J, Genshaft A, Kazer S, Borrajo J, Blainey P, Irvine DJ, Shalek A, Manalis SR. “A microfluidic platform enabling single cell RNA-seq of multigenerational lineages.” Nature Communications. 2016 Jan 6.
  4. Arnold KB*, Szeto GL*, Alter G, Irvine DJ, Lauffenburger DA. “CD4+ T Cell-Dependent and -Independent Cytokine/Chemokine Network Changes in Immune Responses of HIV-infected Individuals.” Science Signaling. 2015 Oct 20. doi: 10.1126/scisignal.aab0808.
    Cover Image/Featured Article; Read Abstract or Free Full Text
  5. Szeto GL, Van Egeren D, Worku H, Sharei A, Alejandro B, Park C, Frew K, Brefo M, Mao S, Heimann M, Langer R, Jensen K, Irvine DJ. “Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines.” Scientific Reports. 2015 May 22. doi: 10.1038/srep10276.
    MIT News article: Freshly squeezed vaccines, Spotlight Image, 2015 May 26
  6. Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, Irvine DJ. “Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants.” The Journal of Clinical Investigation. 2015 May 4. doi: 10.1172/JCI79915.
  7. Hanson MC, Abraham W, Crespo MP, Chen SH, Liu H, Szeto GL, Kim M, Reinherz EL, Irvine DJ. “Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides.” Vaccine. 2015 Jan 2. doi: 10.1016/j.vaccine.2014.12.045.
  8. Castellarnau M*, Szeto GL*, Su H-W, Love JC, Irvine DJ, Voldman J. “Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis.”Small. 2014 Sep 2. doi: 10.1002/smll.201401369.
  9. Jones RB, O’Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD. “Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes.”PLoS Pathog. 2014 Aug 14;10(8):e1004287. doi: 10.1371/journal.ppat.1004287.
  10. Drewes J, Szeto GL, Liao Z, Shearer GM, Zink MC, Graham DRM. “Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.” PLoS ONE. 2014 Apr;9(4):e94375. doi: 10.1371/journal.pone.0094375.
  11. Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. “Structure-based programming of lymph-node targeting in molecular vaccines.” Nature. 2014 Feb 16. doi: 10.1038/nature12978. .
    Faculty of 1000 Prime Recommendations
  12. Irvine DJ, Swartz MA, Szeto GL. “Engineering synthetic vaccines using cues from natural immunity.” Nat Mater. 2013 Nov;12(11):978-90. doi: 10.1038/nmat3775.
  13. Drake A, Joshi NS, Szeto GL, Zhu E, Eisen HN, Irvine DJ. “Koch Institute Symposium on Cancer Immunology and Immunotherapy.” Cancer Immunol Res. 2013 Oct;1:217-222. doi: 10.1158/2326-6066.CIR-13-0116.
  14. Yamanaka YJ*, Szeto GL*, Gierahn T, Forcier T, Benedict KF, Brefo M, Lauffenburger DA, Irvine DJ, Love JC. “Cellular Barcodes for Efficiently Profiling Single-Cell Secretory Responses by Microengraving.” Anal Chem. 2012 Dec 18;84(24):10531-6. doi: 10.1021/ac302264q. Epub 2012 Dec 3.
  15. Szeto GL, Pomerantz JL, Graham DRM, Clements JE. “Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells.” J Biol Chem. 2011 Apr 1;286(13):11275-82. doi: 10.1074/jbc.M110.210518. Epub 2011 Jan 31.
  16. Szeto GL, Brice AK, Yang HC, Barber SA, Siliciano RF, Clements JE. “Minocycline attenuates HIV infection and reactivation by suppressing cellular activation in human CD4+ T cells.” J Infect Dis. 2010 Apr 15;201(8):1132-40. doi: 10.1086/651277.
    Editorial commentary: J Infect Dis. 2010 Apr 15;201(8):1115-1116.
    Faculty of 1000 Prime Recommendations
  17. Wilson DK, Szeto GL, Van Aartsen BH, Noble JM. “A Prototype Acoustic Battlefield Decision Aid with Interfaces to Meteorological Data Sources and a Target Database.” DoD Technical Report # A231293, Oct 2000.
  1. “Delivery Device and Use Thereof For Loading Cell Plasma Membranes.” Szeto GL, Zhang MH, Slaby EM, Irvine DJ. U.S. Provisional Patent Application No. 62/542,842 Filed Aug 9, 2017. Patent pending, 2018.
  2. “Delivery of Biomolecules to Immune Cells.” Sharei AR, Mao S, Hartoularos G, Liu S, Heimann M, Basto P, Szeto GL, Jhunjhunwala S, Irvine DJ, Langer RS, Jensen KF, Von Andrian UH. US Provisional Patent # 62/073,548. Filed Oct 31, 2014. Pub #US 2018/0142198 A1.
  3. “Method and Apparatus for Tracking Cell Identity.” Castellarnau M, Szeto GL, Irvine DJ, Love JC, Voldman J. US Provisional Patent # 14/523,376. Filed Oct 24, 2014. Pub #US 2015/0253237 A1